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KMID : 0380620140460040511
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 4 p.511 ~ p.515
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Inhibitory Effect of Galangin from Alpinia officinarum on Lipopolysaccharideinduced Nitric Oxide Synthesis in RAW 264.7 macrophages
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Lee Hwa-Jin
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Abstract
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In a screen for plant-derived inhibitors of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells, a flavonol isolated from the chloroform extract of Alpinia officinarum was isolated. The structure of the flavonol was found to be 3,5,7-trihydroxy-2-phenylchromen-4-one (galangin, GLG) by using spectroscopy. GLG exhibited an inhibitory effect (IC50 value: 26.8 μM) on NO production in LPS-stimulated RAW 264.7 murine macrophage cells. Moreover, GLG suppressed expressions of inducible nitric oxide synthase (iNOS) protein and mRNA in a dose-dependent manner
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KEYWORD
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Alpinia officinarum, Zingiberaceae, nitric oxide, inducible nitric oxide synthase, flavonol
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